Simon David Henry HOLT
MBE MA MB BChir FRCS

Date of Birth            16 July 1951
Place of birth           Blantyre, Malawi
Nationality               British Citizen
GMC registration    2308085
Email                         simon_holt@mac.com

I am established Consultant General Surgeon running a Breast Unit which diagnosed and treated 350 new breast cancers each year. I have extensive experience in breast ultrasound, guided biopsy and breast reconstruction in addition to all the usual skills expected of a breast surgeon. As Postgraduate Organiser for the Prince Philip Hospital for 10 years from 1991, surgical education supervisor and an undergraduate tutor I have extensive teaching experience. As recent past Chairman of the South Wales Breast Cancer Network, past chairman of the Dyfed-Powys Surgical network and Trust Lead for Cancer Services, I have a wide experience in NHS administration. I have a particular interest in emerging technologies, such as computing, imaging and genetics. I regularly attend local, national and international meetings. All my clinical activity figures are available for audit using the BASO/Canisc databases. Education: School Jan 65 to Dec 69 Ardingly College, Haywards Heath, Sussex 12 O levels 4 A levels Mathematics B Physics A Chemistry A with distinction Biology C University Oct 70 to Jun 73 Kings College, Cambridge Senior Scholar in Medicine First class in parts 1A and 1B Medical Sciences BA in Pathology Jun 73 Medical School University College Hospital, London Sep 73 to Jun 76 Prize in Obstetrics and Gynaecology Medical degree Cambridge University Jun76 Distinction in Surgery Fellowship Primary FRCS (London) Jun 79 Final Fellowship (Edinburgh) Oct 81 Accreditation Royal College of Surgeons, London Oct 87 Postgraduate Appointments: House Physician: University College Hospital Sep 76 to Feb 77 To Dr Stokes and Dr Sarner General Medicine and Gastroenterology House Surgeon: Northwick Park Hospital, Harrow Mar 77 to Aug 77 To Mr A G Cox General Surgery and Surgical Gastroenterology Accident and Emergency: Whipps Cross Hospital Aug 77 to Mar 78 To Dr V Dallos General Accident and Emergency Medicine General Practice: RAF Benson, Oxfordshire May 78 to Nov 79 Responsibility for 1100 forces personnel and their families with special duties to The Queen's Flight Surgical SHO: RAF Hospital, Nocton Hall, Lincoln Nov 79 to Apr 80 To Gp Capt Williams and Wg Cdr Clarke Jan 81 to Dee 81 General and Emergency Surgery Apr 80 to Nov 80 To Wg Cdr Murphy General and Emergency Orthopaedics Nov 80 to Jan 81 Musgrave Park Hospital, Belfast, Northern Ireland To Lt Col K Stevens General and Emergency Surgery Surgical Registrar: RAF Hospital, Wegberg, Germany Jan 82 to Sep 83 To Wg Cdr 1 B Tiwari General and Emergency Surgery Senior Registrar: Peterborough District Hospital, Cambridgeshire Sep 83 to Sep 84 To Mr Young, Mr Hall, Mr Kent, Mr Turner and Mr Holmes. Subspecialty and Emergency General Surgery Oct 84 to Sep 85 The Cade Unit, RAF Hospital, Halton, Buckinghamshire To Air Cdr R Jones and Wg Cdr M Ayres Specialist Oncology and General and Emergency Surgery Oct 85 to Sep 86 St Thomas' Hospital, London To Mr B Jackson and Mr J Nichols Specialist Gastroenterology and General Emergency Surgery Oct 86 to Sep 87 RAF Hospital, Wroughton, Swindon, Wiltshire To Gp Capt M Mahony and Wg Cdr B Morgans Specialist Gastroenterology, Urology and Emergency General Surgery Consultant Surgeon: Consultant Surgical Oncologist Sep 87 to Aug 90 The Cade Unit, RAF Hospital, Halton and Honorary Consultant Surgeon at The Westminster Hospital, London. Aug 90 to present Consultant Surgical Oncologist Peony Breast Care Unit, The Prince Philip Hospital, Llanelli Consultant Surgeon to Breast Test Swansea Offices held: 1. President of Kings College Rowing Club, Cambridge 1972-73 2. Deputy President of The Officers Mess, RAF Nocton Hall 1978-79 3. Deputy Clinical Tutor, RAF Hospital Wegberg 1980-81 4. Membership Secretary to The Military Surgical Society 1986-90 5. Forces Representative to The Association of Surgeons in Training 1987-89 6. Committee Member of The United Services Section of The Royal Society of Medicine 1988-90. 7. Clinical Tutor, RAF Hospital Halton 1988 - 1990 8. Chairman of the Audit Committee, RAF Hospital Halton 1989-1990 9. Postgraduate Organiser, Prince Philip Hospital, Llanelli 1991 - 2000 10. Chairman of the Audit Committee, Prince Philip Hospital, Llanelli 1991 to 1995 and member of the committee since 11. Member of the Clinical Effectiveness Group, Prince Philip Hospital, Llanelli, 1996 – 1999. 12. Chairman of the Dyfed-Powys Surgical Network 2001- 2003 13. Team leader in Surgery, Prince Philip Hospital, Llanelli, 2001 to 2004. 14. Teacher on the ALERT course 2000 – 2010 15. Chairman of The South West Wales Breast Cancer Network 2008 – 2011 the Chairman of the South Wales Breast Cancer Network until April 2014 16. Cancer Services Lead for Hywel Dda Trust Board – Nov 2010 – April 2014 17. Surgical Educational Supervisor, Prince Philip Hospital, Llanelli 1999 to present Publications 1. Holt S D H, Howell G P, Tiwari I B. Phenolisation as an adjunct to Zadik's procedure for ingrowing toenail and onychogryphosis. Journal of The Royal College of Surgeons of Edinburgh 1987; 32: 228-229 2. Holt S D H. Terrorism, hostage-taking and the Stockholm syndrome. Proceedings of The Director General Medical Services Symposium 1985; 83-95. (Classified restricted. General publication denied. 3. Holt S D H, Howell G P, Tiwari I B. Biliary peritonitis following the removal of a T-tube. Journal of The Royal Army Medical Corps 1987; 133: 155. 4. Howell G P, Holt S D H, Tiwari I B. Candida septicaemia and abscess formation following multiple injuries and of the stomach. Journal of The Royal Army Medical Corps 1988; 134: 74-75. 5. Holt S D H. Phenolisation as an adjunct to Zadik's procedure for ingrowing toenail and onychogryphosis. Letter to Journal of the Royal College of Surgeons of Edinburgh 1988; 33: 48. 6. Jones D J, Langstaff R J, Holt S D H, Morgans B T. The value of cystourethroscopy in the investigation of haematuria in the adult male under 40. British Journal of Urology 1988; 62: 541-545. 7. Nichols R J, Holt S D H, Lubowski D Z. Restorative proctocolectomy with ileal reservoir. Comparison of two-stage versus three-stage procedures and an analysis of risk factors that might affect outcome. Diseases of the Rectum and Colon 1989; 32, 342-347. 8. Holt S D H. Surgical aspect of sepsis in acute renal failure. Chapter in "Acute Renal Failure Update 1989," edited Rainford D J, Sweny P. Farrand Press, London 1990. 9. Jones D J, Holt S D H, Surtees P, Coptcoat M J, Davidson D J. A comparison of danazol and placebo in the treatment of adult idiopathic gynaecomastia: the results of a double blind randomised study of 55 patients. Annals of the Royal College of Surgeons of England 1990; 72 (5):296-8. 10. A Deshpande, T Garud, SD Holt, GM Le, CDO'Malley et al. Core biopsy as a tool in planning the management of invasive breast cancer. World J Surg Oncol, 2005 11. Breast Cancer Management in the over 70s. Kannan RY, Khawaja S, Sumrein H, Huws A, Shariaha YM, Holt SDH. BIT Life Sciences’ 3rd Annual World Cancer Congress, Shanghai, April 2010. 12. Oncotype Dx™ in Early Breast Cancer: First UK Prospective Trial. G Bertelli, D Pudney, M Rolles, M Moe, E Brinkworth, S Whelan, S Khawaja, S Holt. National Cancer Research Institute Cancer Conference, Liverpool, November 2010. 13. Gene expression analysis to detect sentinel lymph node involvement. A review of our first 100 cases. Sumrein H, Kawaja S, Shariaha Y, Holt SDH. 13th Milan Breast Cancer Conference, Jun 2010 14. Oncotype Dx versus Notting prognostic index in assessing patients for chemotherapy for breast Cancer. G Bertelli, D Pudney, M Rolles, M Moe, E Brinkworth, S Whelan, S Khawaja, S Holt. St Gallen European Breast Cancer Conference, Mar 2011. 15. The Role of Pre-Operative CT Staging in Determining the Sentinel Lymph Node Status. Saira Khawaja, Ramesh Kannan, Haythem Sumrien, Anita Huws, Yousef Sharaiha, Simon Holt. St Gallen European Breast Cancer Conference, Mar 2011. 16. Digital Breast Tomosynthesis. Y Shariaha, S Khawaja, A Huws, K Nadi, D Premawhadana, S Holt. Association Of Breast Surgeons Meeting, Manchester 2011. 18. Invasive lobular carcinoma of the breast: A retrospective analysis of consecutive cases reviewing size assessment with pre-operative imaging, management and pathological features. A Haragan, A Huws, S Khawaja, S Gurung, K Nadi, Y Sharaiha, S Holt. EBCC Apr 2014 19. Our initial experience of oncoplastic breast conservation surgery. S Khawaja, A Huws, K Nadi, I Patchell, S Khaliq, G Dazeley, A Barnett, Y Sharaiha, S Holt. 20. Preoperative assessment of axillary lymph nodes in patients with early breast cancer. A Huws, I Patchell, S Khawaja, K Nadi, S Khaliq, G Dazeley, A Barnett, Y Sharaiha, S Holt. Breast 2251 (2103) S71 21. Breast cancer surgery is safe in the elderly. R Kannan, K Nadi, S Khawaja, H Sumrein, S Holt, Y Sharaiha. International Journal of Surgery 11 (2013) 605 22. Digital breast tomosynthesis: A review of the first 1000 patients imaged. S Holt, A Moalla, s Khawaja, A Birch, M Adnan, D Premawardhana, K Nadi, Y Sharaiha. 23. Our intial experience of digital breast tomosynthesis(DBT) in terms of radiation safety and reporting. S Khawaja, M Adnan, A Premawardhana, A Burch, S Holt 24. Breast pain patients: Does every woman need ammography? K Nadi, A Huws, S Khawaja, Y Sharaiha, S Holt. KCCC14 meeting, Kyoto, Japan 2014 25. A decision impact, decision conflict and economic assessment of routine Oncotype DX testing of 146 women with node-negative or pNImi, ER-positive breast cancer in the UK. S Holt, G Bertelli, I Humphreys, W Valentine, S Durrani, D Pudney, M Rolles,M Moe, S Khawaja, Y Sharaiha, E Brinkworth, S Whelan, S Jones, H Bennett, C J Phillips. BJC (2013) 108, 2250-2258 26. Metasin – intra-opertive RT-qPCR Assey to detect metastatic cancer in sentinel lymph nodes. Salma Al-Ramadhani, Priya Sai-Giridhar, Dilushana George, Preethi Gopinath Evdokia Arkoumani, Samar Jader, Maryse Sundaresan, Roberto Salgado,Dennis Larsimont, Stephen A. Bustin and Vasi Sundaresan. Int. J. Mol. Sci. 2013, 14 (From my department) 27. Pooled analysis of 4 European studies assessing the impact of Oncotype DX on treatment decisions. J Albanell, J Gligorov, S Holt, J Blohmer, W Eirmann, C Svedman. St Gallen European Breast Conference Mar 2013 28. Metasin: A Novel Rapid RT-PCR Assay for the Analysis of Sentinel Lymph Nodes from Patients with Breast Cancer, in the Intra-Operative Setting: Analysis of the First 1000 Cases. Al-Ramadhani S, Balaraman P, George D, Holt S, Sundaresan, V , et al. Ghent Pathology Conference 2011. 29. Results from a prospective clinical study on the impact of Oncotype DX® on adjuvant treatment decision making in a cohort of 142 UK patients. S Holt, S Durrani, D Pudney, M Rolles, M Moe, S Khawaj1, Y Sharaiha, S Pitcher, E Brinkworth, S Whelan, S Jones, U Laggner, G Bertelli. Poster presented at the 34th Annual San Antonio Breast Cancer Symposium, December 6-10, 2011, number PD5-14-26 30. Cost-effectiveness evaluation of the Oncotype DX® breast cancer assay in clinical practice in the UK. Simon DH Holt, Hayley Bennett, Gianfilippo Bertelli, William J Valentine, Ceri J Phillips. Poster presented at the 34th Annual San Antonio Breast Cancer Symposium, December 6-10, 2011, number PD06.02 31. Metasin: A rapid intraoperative NHS assay for assessment of sentinel lymph nodes from breast cancer patients. S Al-Ramadhani, P Sai-Giridhar, S Holt, I Cree, C Ylangou, N Agarawal, M Jeffrey, V Sundaresan.The bulletin of the Royal College of Pathologists, 161-3, no. 167, Jul 14 32. Invasive lobular carcinoma of the breast: A retrospective analysis of consecutive cases reviewing size assessment with preoperative imaging, management and pathological features. A Haragan, a Huws, S Khaliq, N muniweera, S Gurung, K Nadi, Y Sharaiha, S Holt. P095, European Breast Cancer Conference, 19 Mar 2014 33. Meta-analysis of prospective european studies assessing the impact of using the 21-gene recurrence score assay on clinical decision making in women with er-positive, her2-negative early stage breast cancer. J. Albanell · S. Holt · J. Gligorov · W. Eiermann · C. Svedman. ESMO Annals of Oncology · September 2012  34. Impact of nodal disease on the outcomes following neoadjuvant chemotherapy. Sujatha Udayasankar · Asma Munir · Anita Huws · Saira Khawaja · Yousef Sharaiha · Simon Holt Article · ABS May 2016 DOI: 10.1016/j.ejso.2016.02.068 35. Long-term survival analysis of breast cancer patients treated with neoadjuvant chemotherapy. Asma Munir · Sujatha Udayasankar · Anita Huws · Gill Dazeley · Yousef Sharaiha · Simon Holt · Saira Khawaja ABS · May 2016 DOI: 10.1016/j.ejso.2016.02.059 36. The oncological outcomes of Breast Conservation Surgery (BCS) following Neoadjuvant Chemotherapy (NACT). Sujatha Udayasankar · Asma Munir · Anita Huws ·Angela Barnett · Yousef Sharaiha · S.D.H. Holt · Saira Khawaja Article · DOI: 10.1016/j.ejso.2016.02.062 37. Survival analysis of patients receiving neoadjuvant chemotherapy in inflammatory vs non-inflammatory locally advanced breast cancer. Asma Munir · Sujatha Udayasanka · Anita Huws ·Angela Barnett · Yousef Sharaiha · Simon Holt · Saira Khawaja ABS · May 2016 38. Long term recurrence outcome of patients undergoing oncotype Dx testing for ER positive and node negative early breast cancer. Asma Munir · Sujatha Udayasanka · Daniel Thomas ·Anita Huws · Gill Dazeley · Yousef Sharaiha · Saira Khawaja · Simon Holt. ABS May 2016 DOI: 10.1016/j.ejso.2016.02.064 39. Our initial experience of digital breast tomosynthesis guided vacuum assisted breast biopsies and the patient's perspective: A single centre experience. Asma Munir · Anita Huws · Ali Moalla · Sujatha Udayasankar · Helen Williams · Eleri Lodwich · Yousef Sharaiha · Saira Khawaja · Simon Holt Article · May 2016 DOI: 10.1016/j.ejso.2016.02.051 40. The long term follow up of patients undergoing oncotype Dx testing in a multicenter study in southwest Wales, UK. S. Khawaja · S. Udayasankar · A. Munir · D. Thomas · A. Huws · Y. Shariaha · S. Holt Article · European Journal of Cancer 57:S7-S7 · April 2016 41. Our first experience of oncotype dx in early breast cancers. S. Khawaja · Y. Sharaiha · S. Pitcher · S. Whelan · E. Brinkworth · D. Pudney · M. Moe · M. Rolles · G. Bertelli · S. Holt St Gallen · Conference Paper in Annals of Oncology · May 2011 42. The Metasin-BLNA, intra-operative assessment of Sentinel Lymph Nodes from Breast Cancer Patients: CE Marking of the Metasin Assay for wider use. D. George · A. McDowell · P. Sai-Gridar · S. Holt · G. Gabrielle · M. Jeffreys · M. Balhause · O. Landt · V. Sundaresan. Journal of Pathology Apr 2013 43. Metasin: A Novel Rapid RT-PCR Assay for the Analysis of Sentinel Lymph Nodes from Patients with Breast Cancer, in the Intra-Operative Setting: Analysis of the First 1000 Cases. S. Al-Ramadhani · P. Balaraman · D. George · M. Morgan· S. Jader · A. McDowell · F. G. Gabriel · J. McKenzie · S. Al-Sam · S. Holt · R. Mansel · I. Cree · M. Keshtgar · N. McDermott · D. Larsimont · S. A. Spinette · R. Salgado ·E. Arkoumani · V. Sundaresan. The Journal of Pathology · July 2011 44. The Metasin-BLNA, the NHS Solution, qPCR Real Time Assay for the detection of Metastatic Cancer in Sentinel Lymph Nodes from Patients with Breast Cancer: Running Live at Harlow and Portsmouth: The 1000 case milestone reached. S. Holt · S. Al-Ramadhani · S. Bustin · S. Al-sam · V. Sundaresan · P. Sai-Gridar · D. George · M. Morgan · A. McDowell · G. Gabrielle · S. Jader · R. Mansel · I. Cree/ The Journal of Pathology · March 2012 45. Article: A Multi-Centre Validation of Metasin: a molecular assay for the Intraoperative assessment of Sentinel Lymph Nodes from Breast Cancer Patients. Priya Sai-Giridhar · Salma Al-Ramadhani · Dilushana George · Preethi Gopinath · William Andrews · Samar Jader · Shelley Brown · Alison Findlay · Evdokia Arkoumani · Salam Al-Sam · [...] · Keshtgar Mo ·McDermott Nuala · El Sheikh Soha · Wellsted David ·Collard Jade · Chaplin Hema · Landt Olfert · Bustin Stephen · Sundaresan Maryse · Sundaresan Vasi. Histopathology · September 2015. 46. Article: Breast implant extrusion related to Herpesviridae. Darmiga Thayabaran · Abrar Saiyed · Anita Maria Huws ·Saira Khawaja · Simon Holt. Aug 2015 · International Journal of Surgery Case Reports 47. Article: Can synthetic 2D mammography be used to select patients in whom there is no need to review the digital breast tomosynthesis from which they were constructed? A review of 1871 consecutive mammogram sets of patients presenting symptomatically or for follow: Simon DH Holt · Ali Moalla · Helen R Williams ·Khaldoun MY Nadi · Anita M Huws · Amrita Gurung ·Daniel Thomas · Yousef M Sharaiha. SABCS May 2015 · Cancer Research 48. Article: Abstract P2-02-02: A review of the accuracy of wire localisation using digital breast tomosynthesis (DBT) in a prospective series of 81 patients. Simon DH Holt · Khaldoun MY Nadi · Amrita Gurung ·Helen R Williams · Anita M Huws · Yousef M Sharaiha. Cancer Research 75(9 Supplement):P2-02-02-P2-02-02 · May 2015 49. Article: Our initial experience of oncoplastic breast conservation surgery. Saira Khawaja · Anita Huws · Khaldoun Nadi · Ifan Patchell · Shahzad Khaliq · Gill Dazeley · Angela Barnett· Yousef Sharaiha · Simon Holt. May 2013 · European Journal of Surgical Oncology 50. Article: Abstract P1-01-18: The results of 55 consecutive cases of intra-operative sentinel node analysis using real time polymerase chain reaction detection of cytokeratin 19 and mammoglobin expression (Metasin) to direct immediate axillary clearance. K. Nadi · Y. Sharaiha · P. Sai-Girdhar · A. Huws · S. Khawaja · S. Holt. Cancer Research 72(24 Supplement):P1-01-18-P1-01-18 · December 2012 51. Article: PD06-02: Cost-Effectiveness Evaluation of the Oncotype DX(R) Breast Cancer Assay in Clinical Practice in the UK. SDH Holt · H. Bennett · G. Bertelli · WJ Valentine · CJ Phillips. Cancer Research 71(24 Supplement):PD06-02-PD06-02 · February 2012 52. Article: A review of the assessment of male breast patients, with special reference to the use of imaging with digital breast tomosynthesis (DBT) and sonography. Shazad Khaliq · Anita Maria Huws · T. Ifan Patchell ·Kanwaljit Dhande · Saira Khawaja · Khaldoun Nadi ·Yousef Sharaiha · Simon Holt. European Journal of Surgical Oncology 40(5):638 · May 2014 53. Article: P5-14-26: Results from a Prospective Clinical Study on the Impact of Oncotype DX on Adjuvant Treatment Decision Making in a Cohort of 142 UK Patients. S. Holt · G. Bertelli · E. Brinkworth · S. Durrani · S. Jones ·S. Khawaja · U. Laggner · M. Moe · D. Pudney · S. Pitcher· M. Rolles · Y. Sharaiha · S. Whelan. Cancer Research 71(24 Supplement):P5-14-26-P5-14-26 · February 2012 54. Article: 15. Metasin-BLNA, the NHS solution for the intra-operative assessment of sentinel lymph nodes from breast cancer patients: The multi-centre validation of 1265 cases Salma Al Rhamadhani · Priya Sai-Giridhar · Mike Morgan· Samar Jader · Dilu George · Ian Cree · Simon Holt ·Amanda McDowell · Soha Sheikh · Mohamed Keshtgar ·Francis Guy Gabriel · Evdokia Arkoumani · Jolanta McKenzie · Robert Mansell · Salam Al-Sam · Nuala McDermott · Vasi Sundaresan. European Journal of Surgical Oncology 38(11):1138 · November 2012 55. Article: P196 Results from a prospective clinical study on the impact of Oncotype DX on adjuvant treatment decision and risk classification by Nottingham prognostic index (NPI) and recurrence score (RS). S. D. H. Holt · G. Bertelli · D. Pudney · M. Rolles · M. Moe· E. Brinkworth · S. Wheelan · S. Khawaja · S. Pitcher · Y. Sharaiha. DOI: 10.1016/S0960-9776(11)70137-0, Mar 2011 · The Breast 56. Article: Metasin-BLNA: The NHS Solution Cost Effective-Rapid Intraoperative Molecular Assessment of Sentinel Lymph Nodes from Breast Cancer Patients. Vasi Sundaresan · S. Al-Ramadhani · P. Balaraman · S. Holt · R. Mansel · I. Cree · D. Larsimont · R. Salgado. DOI: 10.1016/S0960-9776(11)70137-0 May 2011 · European Journal of Surgical Oncology 57. Article: Digital Breast Tomosynthesis (DBT). A review of the first 1000 patients imaged. Simon Holt · A. Moalla · S. Khawaja · A. Birch · M. Adnan· D. Premawardhana · K. Nadi · Y. Sharaiha. DOI: 10.1016/j.ejso.2011.03.100, May 2011 · European Journal of Surgical Oncology 58. Article: Gene expression analysis to detect sentinel lymph node involvement. A review of our first 100 cases. Haytham Sumrien · R. Kannan · S. Khawaja · G. Tewari ·Y. Sharaiha · S. Holt. Article – DOI: 10.1016/j.ejso.2010.08.009Nov 2010 – EJSO. 59. Article: P174 Our initial experience of digital breast tomosynthesis (DBT) in terms of radiation safety and reporting. S. Khawaja · M. Adnan · A. Premawardhana · A. Burch ·A. Huws · K. Nadi · Y. Sharaiha · S. Holt. Article · Mar 2011 · The Breast DOI: 10.1016/S0960-9776(11)70117-5 60. Article: 88. Validity of Oncotype Dx recurrence score in predicting recurrence in hormone receptor positive and node negative early breast cancer patients. A. Munir  S. Udyashankar +5 more authors...  S. Holt. DOI: 10.1016/j.ejso.2016.06.094 61. Article: 93. The impact of the Oncotype Dx recurrence score on treatment decisions and clinical outcomes in patients with early stage lobular breast cancer A Munir, S Udayasankar, D Thomas, S D Holt. DOI: 10.1016/j.ejso.2016.06.099 62. Article: Impact of nodal disease on the outcomes following neoadjuvant chemotherapy. Sujatha Udayasankar  Asma Munir +2 more authors...  Simon Holt. DOI: 10.1016/j.ejso.2016.02.068 63. Article: Abstract S1-09: A comparison of the diagnostic performance of 2D synthetic mammography versus digital breast tomosynthesis in 2500 patients: SD Holt  YM Sharaiha +2 more authors...   AM Huws. Feb 2016 · Cancer Research DOI: 10.1016/j.ejso.2016.06.094 64. Article: Abstract P1-02-02: A review of 66 consecutive patients investigated for mammographic abnormalities by digital tomosynthesis guided vacuum assisted breast biopsy. A Munir   A Moalla +2 more authors...   SD Holt. Cancer Research 76(4 Supplement):P1-02-02-P1-02- 02 · February 2016 DOI: 10.1158/1538-7445.SABCS15-P1-02-02 65. Article: Abstract P2-01-07: Neutrophil lymphocyte ratio and breast cancer: A future prognostic indicator for outcome after surgery? GJ Williams · AM Huws · SDH Holt · YM Sharaiha. Cancer Research 76(4 Supplement):P2-01-07-P2-01-07 · February 2016 DOI: 10.1158/1538-7445.SABCS15-P2-01-07 66. Article: Titanium-coated polypropylene mesh for immediate implant-based reconstruction: Our initial experience. A Munir, S Udayasankar, A Huws, A Barnett, S Holt, Y Sharaiha, S Khawaja. ABS poster, Belfast May 16 67. Article: Prediction of further axillary node metastatic load in breast cancer using the Metasin RTqPCR assay for CK19 and Mammaglobin during intra-operative node analysis. S Udayasankar, A Huws, P Gai-Giridhar, a Munir, S Holt, Y Sharaiha, S Khawaja. ABS poster, Belfast May 16 68. Article: Efficiency of Digital Breast Tomosynthesis (DBT) in preoperative wire localisation of non-palpable lesions. A Munir, S Udayasankar, A Huws, S Holt, Y Sharaiha, S Khawaja. ABS poster, Belfast May 16 69. Article: Predictive factors for recurrence following neo-adjuvant chemotherapy and definitive surgery for stage 2 and 3 breast cancer. Z Feroza, A Munir, S Udayasankar, S Holt, Y Sharaiha, S Khawaja. ECCO poster Mar 2017 Major Papers Presented 1. Hostage-taking and the Stockholm syndrome. Military Surgical Society, Berlin, 1983. 2. Limb trauma and renal failure. Travelling Surgeons Club, RAF Halton, 1985. 3. Interrogation and torture. Getting at the truth? First International Meeting of The Military Surgical Society. Paris 1986. 4. The surgical indications for enteral and parenteral nutrition. Conference on enteral and parenteral feeding, Swindon, 1987. 5. The surgical aspects of the treatment of acute renal failure. International Symposium on acute renal failure, Royal Free Hospital, London, 1989. 6. Restorative proctocolectomy: techniques and complications. Tri-service Surgical Meeting, Institute of Naval, Gosport, 1989. 7. Vasectomy. A guide to patients considering sterilisation. Director General Medical Services (RAF) RAF Halton, Aylesbury, 1989. 8. A complete audit of 5 year survival after surgical treatment for breast cancer for the years 1993 – 1995 stratified by Nottingham prognostic index. Conversazione, Singleton Hospital, Swansea, 1994. 9. Argon diathermy and blood loss at mastectomy. Conversazione, Singleton Hospital, Swanseaa, 1994. 10. Medicine Meets Virtual Reality. A Guide for Non-Nerds. Invited Lecture at The Association of Clinical Tutors, various other venues in the UK. 11. What risk? An evaluation of risk associated with environmental pollution. Invited lecture Prince Philip Hospital. 12. The Human Genome in Five Easy Chapters. Invited lecture University of Malaya, Kuala Lumpur 2000. 13. Technical Developments and the Future Diagnosis and Treatment of Breast Cancer. Various venues including The University of Malaya. Kuala Lumpur. 2001 14. RTPCR intraoperative Sentinel nodes analysis. A clinical and economic analysis of the first 70 cases. All Wales Breast Cancer Meeting, Cardiff 2009. 15. Treating breast cancer in the over 70’s. A review of 150 cases. . All Wales Breast Cancer Meeting, Cardiff 2009. 16. Oncotype Dx: Decision impact, decision conflict and economic analyses – various aspects presented in London, Madrid, Hamburg, Istanbul, Dubai, Beirut and Karachi meetings. 17. Is Oncotype DX good value for our health care systems? Invited lecture ESSO web conferencing series Sep 12 18. Vacuum assisted biopsy. Invited lecture, Hologic training course Nottingham, Birmingham and Glasgow 2012 – 2017. 19. Ten good reasons to continue follow up. South Wales Breast Cancer Network meeting Feb 2012 20. Is there any future for surgery in the treatment of breast cancer? South Wales Breast Cancer Network meeting Feb 2013 21. Whatever next for breast cancer treatments? South Wales Breast Cancer Network meeting Feb 2014. 22. Gene expression analysis for predicting chemotherapy benefit. Middle East breast Cancer conference, Dubai, UAE Nov 2013. 23. Advanced imaging of beast cancer. Pakistan Breast Conference, Karachi, Mar 2104. 24. A comparison of 2D synthetic mammography and digital breast tomosynthesis in 2500 patients. Oral presentation San Antonio Breast Cancer Symposium Dec 2015. and more recently lectures on Gene expression analysis at venues in Hong Kong, China, South Korea, Japan, South Africa and Thailand Chief Investigator: Treatment and economic impact of routine Oncotype Dx (gene expression analysis of breast cancers). Chief Investigator: Oncotype node negative trial Oncotype node positive trial Principal Investigator: Poetic Trial EPHOS-B Trial Attom Trial Azure Trial IBIS-2 trial React Trial Glacier trial Icicle trial Atac trial Loris trial Mammo-50 Fund Raising: Over the last 10 years I have raised £2 million in funds for the Breast Care Unit. I oversaw the building of the £180,000 first phase of the new breast care facility which was opened in Oct 2001. I have overseen the 8 million pound second phase which is now complete and acknowledged as one of the most advanced in the world. Interests: Travel to out of the way places, skiing, modern music and computers. Family: I am married to Zhihong (Xixi) and we have 2 children. I live in Llanelli, Wales, UK Contact: Phone: 01554 783386 Fax 01554 783736 E-mail simon_holt@mac.com Signed: Dated: 27 May 17 Simon D H Holt